Clinical diagnostics are moving towards minimally-invasive procedures that allow the early detection of disease, as well as monitoring of disease status and treatment efficacy. These methods rely on the ability to detect “red flags” of diseases, referred as biomarkers, in body fluids from patients. Given the relatively new field of extracellular vesicles (EVs) study, data is now emerging on their characteristics and functions. These recently identified nanoparticles contain a sample of material found in the diseased cells of the patients and are a promising source of biomarkers in biological fluids.
However, there are currently obstacles to the application of EVs in the clinical setting which include the quick and robust isolation of required quantities of EVs from various body fluids as well as the enrichment of EVs from diseased cells among mixtures of vesicular material originating from multiple cell types.
The promising characteristics of EVs make them a fast growing area of research and translational medicine due to their applications in areas where repetitive and non-invasive collection and analysis of biomarkers from biological fluids is desired. Therefore, there is a pressing need to develop rapid and versatile disease-specific EV isolation and diagnostic technologies.
We can offer you access to the Vn96 platform technology to overcome many of these challenges by isolating and purifying specific EVs originating from diseased cells, minimizing process time and using existing infrastructure. Yields of EVs purified using Vn96 prove to be better than other established methods of EV isolation, as evaluated by protein content and nanoparticle tracking analysis.
Benefits of using the Vn96 isolation technology include
- Use in diagnostics, monitoring of disease status and treatment efficacy
- Sample analysis from biological fluids
- Non-invasive or minimally-invasive
- No need for ultracentrifuge
- Sample processing in minutes versus hours
- Cardiovascular diseases
- Neurodegenerative diseases
- Metabolic diseases
- Other diseases