We have engineered and validated a synthetic peptide (Vn96) with specific affinity for canonical heat shock proteins (HSPs) as a tool for rapid isolation and purification of HSPcontaining extracellular microvesicles  (eMVs). In most cancers HSP expression is exceptionally high (chaperonopathies) and found on the surface of their secreted eMVs. Thus, our method isolates cancer specific eMVs of highest clinical value and also compares favourably in terms of efficiency, cost and platform versatility. As part of the validation process for Vn peptides, we performed comparative genomic and proteomic characterizations of the eMV subsets obtained by Vn affinity protocol with those from established protocols such as ultracentrifugation and a commercial isolation reagent. The compatibility of Vn affinity technology with such downstream "omics" applications as next-generation sequencing (NGS) and mass spectrometry (MS) is essential for its ultimate use in the search for clinical biomarkers present in eMVs.

Excipio Technologies Inc.

35 Providence Street
Moncton, New Brunswick
E1C 8X3

METM Kit product information:

Business Development Contact:
Remi Richard
Business Development Agent
Phone : +1 506 869 2048
Fax : +1 506 862 7571

Unlock the diagnostic potential of exosomes

Increase the specificity and sensitivity of your biofluid-based molecular diagnostic assays with Vn96. The Vn96 platform technology can give you access to improved clinical diagnostics directly on site or at point-of-care with faster, more specific and efficient exosome isolation. All while using your existing infrastructure, minimizing your isolation time to less than an hour and eliminating the need for ultracentrifugation or expensive antibodies and filtration methods.
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